Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis.

Cancer cell - 12 Feb 2018

Cortes Jose R, Ambesi-Impiombato Alberto, Couronné Lucile, Quinn S Aidan, Kim Christine S, da Silva Almeida Ana C, West Zachary, Belver Laura, Martin Marta Sanchez, Scourzic Laurianne, Bhagat Govind, Bernard Olivier A, Ferrando Adolfo A, Palomero Teresa

Abstract excerpt

Angioimmunoblastic T cell lymphoma (AITL) is an aggressive tumor derived from malignant transformation of T follicular helper (Tfh) cells. AITL is characterized by loss-of-function mutations in Ten-Eleven Translocation 2 (TET2) epigenetic tumor suppressor and a highly recurrent mutation (p.Gly17Val) in the RHOA small GTPase. Yet, the specific role of RHOA G17V in AITL remains unknown. Expression of Rhoa G17V in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Dioxygenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, T-Cell

Share to Mice, Knockout

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins

Share to rhoA GTP-Binding Protein

Share to T-Lymphocytes, Helper-Inducer

Source

Open in PubMed Open full text

Identifiers

PMID: 29398449
DOI: 10.1016/j.ccell.2018.01.001
PMCID: PMC5811310

Genes

RHOA
ICOS
CD4
TET2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis.PMID 29398449Read ↗

RHOA G17V induces T follicular helper cell specification and involves angioimmunoblastic T-cell lymphoma via upregulating the expression of PON2 through an NF-κB-dependent mechanismSemantic proximity Read ↗

The curious origins of angioimmunoblastic T-cell lymphoma.Semantic proximity Read ↗

Angioimmunoblastic T-cell Lymphomas With the RHOA p.Gly17Val Mutation Have Classic Clinical and Pathologic Features.Semantic proximity Read ↗

Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis.Semantic proximity Read ↗

Clinicopathologic Analysis of Angioimmunoblastic T-cell Lymphoma With or Without RHOA G17V Mutation Using Formalin-fixed Paraffin-embedded SectionsSemantic proximity Read ↗

Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation.Semantic proximity Read ↗

Follicular helper T‐cells: expanding roles in T‐cell lymphoma and targets for treatmentSemantic proximity Read ↗

IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma.Semantic proximity Read ↗

RHOA mutation in follicular T-cell lymphoma: Clinicopathological analysis of 16 cases.Semantic proximity Read ↗

A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma.Semantic proximity Read ↗

Angioimmunoblastic T cell lymphoma: novel molecular insights by mutation profiling.Semantic proximity Read ↗

Clinicopathological Implications of RHOA Mutations in Angioimmunoblastic T-Cell Lymphoma: A Meta-analysis: RHOA mutations in AITL.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.