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Article

Low fraction of the 222K PrP variant in the protease-resistant moiety of PrPres in heterozygous scrapie positive goats.

The Journal of general virology - 1 Jul 2017

Mazza Maria, Guglielmetti Chiara, Ingravalle Francesco, Brusadore Sonia, Langeveld Jan P M, Ekateriniadou Loukia V, Andréoletti Olivier, Casalone Cristina, Acutis Pier Luigi

Abstract excerpt

The presence of lysine (K) at codon 222 has been associated with resistance to classical scrapie in goats, but few scrapie cases have been identified in 222Q/K animals. To investigate the contribution of the 222K variant to PrPres formation in natural and experimental Q/K scrapie cases, we applied an immunoblotting method based on the use of two different monoclonal antibodies, F99/97.6.1 and SAF84, chosen for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28691895
DOI: 10.1099/jgv.0.000843
PMCID: PMC5656779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Low fraction of the 222K PrP variant in the protease-resistant moiety of PrPres in heterozygous scrapie positive goats.PMID 28691895Read ↗

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