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Article

Protease-resistant prion protein in brain and lymphoid organs of sheep within a naturally scrapie-infected flock.

Microbial pathogenesis - 1 Jun 2000

Madec J Y, Groschup M H, Calavas D, Junghans F, Baron T

Abstract excerpt

The hallmark of transmissible spongiform encephalopathies (TSE), such as scrapie in sheep, is the accumulation in tissues of an insoluble and protease resistant form (PrPres) of the cellular prion protein. In this study, we evaluated whether the diversity in both the clinical pattern and the PrP genotypes of scrapied sheep from the same flock was connected with different levels and/or glycoform patterns of the...

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Identifiers

PMID: 10839972
DOI: 10.1006/mpat.2000.0357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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