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Article

PRNP variants in goats reduce sensitivity of detection of PrP(Sc) by immunoassay.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc - 1 May 2015

Madsen-Bouterse Sally A, Schneider David A, Dassanayake Rohana P, Truscott Thomas C, Zhuang Dongyue, Kumpula-McWhirter Nancy, O'Rourke Katherine I

Abstract excerpt

Diagnostic analyses often employ single antibody systems but are potentially limited by epitope sequence variation. United States regulatory testing for scrapie primarily uses antibody F99/97.6.1 for immunohistochemistry (IHC) of the prion protein associated with scrapie (PrP(Sc)). Whereas the epitope bound by F99/97.6.1 is highly conserved in sheep, a polymorphism in caprine PRNP results in a glutamine to lysine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26038481
DOI: 10.1177/1040638715585865

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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PRNP variants in goats reduce sensitivity of detection of PrP(Sc) by immunoassay.PMID 26038481Read ↗

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