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Article

Sensitivity of the Western blot detection of prion protein PrPres in natural sheep scrapie.

Journal of virological methods - 1 Nov 1998

Madec J Y, Groschup M H, Buschmann A, Belli P, Calavas D, Baron T

Abstract excerpt

The sensitivity of Western blot detection of PrPres using two different extraction procedures on brain material of 30 scrapie-affected sheep was compared. Whereas PrPres could be detected in all sheep after extraction with the first method, 30% did not give any signal after extraction with the second method. However, the second method, when positive, permitted the detection of PrPres from smaller amounts of...

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PMID: 9870592
DOI: 10.1016/s0166-0934(98)00113-x

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