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Article

Methods to generate genetically engineered mouse models of soft tissue sarcoma.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015

Dodd Rebecca D, Añó Leonor, Blum Jordan M, Li Zhizhong, Van Mater David, Kirsch David G

Abstract excerpt

We discuss the generation of primary soft tissue sarcomas in mice using the Cre-loxP system to activate conditional mutations in oncogenic Kras and the tumor suppressor p53 (LSL-Kras(G12D/+); p53(flox/flox)). Sarcomas can be generated either by adenoviral delivery of Cre recombinase, activation of transgenic Cre recombinase with tamoxifen, or through transplantation of isolated satellite cells with Cre activation...

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Identifiers

PMID: 25636474
DOI: 10.1007/978-1-4939-2297-0_13
PMCID: PMC5612825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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