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Article

Genetic variants and evolutionary analyses of heparin cofactor II.

Immunobiology - 1 Sept 2014

Kumar Abhishek, Bhandari Anita, Sarde Sandeep J, Goswami Chandan

Abstract excerpt

Heparin cofactor II (HCII) belongs to serpin superfamily and it acts as a thrombin inhibitor in the coagulation cascade, in a glycosaminoglycan-dependent pathway using the release of a sequestered hirudin-like N-terminal tail for interaction with thrombin. This serpin belongs to multiple member group V2 of vertebrate serpin classification. However, there is no comprehensive study illustrating the exact...

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PMID: 24950623
DOI: 10.1016/j.imbio.2014.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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