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Article

Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites.

Journal of molecular biology - 1 Oct 2010

Ho Meng-Ru, Lou Yuan-Chao, Wei Shu-Yi, Luo Shih-Chi, Lin Wen-Chang, Lyu Ping-Chiang, Chen Chinpan

Abstract excerpt

Human RegIV protein, which contains a sequence motif homologous to calcium-dependent (C-type) lectin-like domain, is highly expressed in mucosa cells of the gastrointestinal tract during pathogen infection and carcinogenesis and may be applied in both diagnosis and treatment of gastric and colon cancers. Here, we provide evidence that, unlike other C-type lectins, human RegIV binds to polysaccharides, mannan, and...

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Source

Identifiers

PMID: 20692269
DOI: 10.1016/j.jmb.2010.07.061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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