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Article

Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1.

Glycobiology - 1 Dec 2008

Nishi Nozomu, Abe Akemi, Iwaki Jun, Yoshida Hiromi, Itoh Aiko, Shoji Hiroki, Kamitori Shigehiro, Hirabayashi Jun, Nakamura Takanori

Abstract excerpt

Galectin-1 (Gal-1), a member of the beta-galactoside-binding animal lectin family, has a wide range of biological activities, which makes it an attractive target for medical applications. Unlike other galectins, Gal-1 is susceptible to oxidation at cysteine residues, which is troublesome for in vitro/vivo studies. To overcome this problem, we prepared a cysteine-less mutant of Gal-1 (CSGal-1) by substituting all...

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Identifiers

PMID: 18796645
DOI: 10.1093/glycob/cwn089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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