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Article

Biomolecular Recognition of the Glycan Neoantigen CA19-9 by Distinct Antibodies.

Journal of molecular biology - 23 Jul 2021

Borenstein-Katz Aliza, Warszawski Shira, Amon Ron, Eilon Maayan, Cohen-Dvashi Hadas, Leviatan Ben-Arye Shani, Tasnima Nova, Yu Hai, Chen Xi, Padler-Karavani Vered, Fleishman Sarel Jacob, Diskin Ron

Abstract excerpt

Glycans decorate the cell surface, secreted glycoproteins and glycolipids, and altered glycans are often found in cancers. Despite their high diagnostic and therapeutic potential, however, glycans are polar and flexible molecules that are quite challenging for the development and design of high-affinity binding antibodies. To understand the mechanisms by which glycan neoantigens are specifically recognized by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34119488
DOI: 10.1016/j.jmb.2021.167099
PMCID: PMC7611348

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