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Article

X-ray structure of a protease-resistant mutant form of human galectin-8 with two carbohydrate recognition domains.

The FEBS journal - 1 Oct 2012

Yoshida Hiromi, Yamashita Satoshi, Teraoka Misa, Itoh Aiko, Nakakita Shin-ichi, Nishi Nozomu, Kamitori Shigehiro

Abstract excerpt

Galectin-8 is a tandem-repeat-type β-galactoside-specific animal lectin possessing N-terminal and C-terminal carbohydrate recognition domains (N-CRD and C-CRD, respectively), with a difference in carbohydrate-binding specificity, involved in cell-matrix interaction, malignant transformation, and cell adhesion. N-CRD shows strong affinity for α2-3-sialylated oligosaccharides, a feature unique to galectin-8. C-CRD...

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Identifiers

PMID: 22913484
DOI: 10.1111/j.1742-4658.2012.08753.x

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