Article

Biomolecular recognition of the glycan neoantigen CA19-9 by distinct antibodies

2021-02-17

Abstract excerpt

<h4>ABSTRACT</h4> Glycans decorate cell surface, secreted glycoproteins and glycolipids. Altered glycans are often found in cancers. Despite their high diagnostic and therapeutic potentials, glycans are polar and flexible molecules that are quite challenging for the development and design of high-affinity binding antibodies. To understand the mechanisms by which glycan neoantigens are specifically recognized by a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 41366d3f-ac5c-508a-8ceb-204b61fa85a4
DOI: 10.1101/2021.02.17.431565

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Biomolecular recognition of the glycan neoantigen CA19-9 by distinct antibodiesDOI 10.1101/2021.02.17.431565Read

Biomolecular Recognition of the Glycan Neoantigen CA19-9 by Distinct Antibodies.Semantic proximity Read

Directed Evolution of Therapeutic Antibodies Targeting Glycosylation in CancerSemantic proximity Read

Structural basis of a high-affinity antibody binding to glycoprotein region with consecutive glycosylation sitesSemantic proximity Read

Smaller size packs a stronger punch - Recent advances in small antibody fragments targeting tumour-associated carbohydrate antigensSemantic proximity Read

An Integrative Approach to Develop and Characterise Antibodies Against the Cancer Associated Antigen Sialyl Lewis A (CA 19-9)Semantic proximity Read

Glycoproteogenomics: Setting the Course for Next-Generation Cancer Neoantigen Discovery for Cancer VaccinesSemantic proximity Read

Antigen binding by conformational selection in near-germline antibodiesSemantic proximity Read

A structure-based engineering approach to abrogate pre-existing antibody binding to biotherapeuticsSemantic proximity Read

BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain.Semantic proximity Read

Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigensSemantic proximity Read

Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigensSemantic proximity Read

Glycosylation Shapes the Efficacy and Safety of Diverse Protein, Gene and Cell TherapiesSemantic proximity Read