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Article

An asbestos-exposed family with multiple cases of pleural malignant mesothelioma without inheritance of a predisposing BAP1 mutation.

Cancer genetics - 1 Oct 2015

Cheung Mitchell, Kadariya Yuwaraj, Pei Jianming, Talarchek Jacqueline, Facciolo Francesco, Visca Paolo, Righi Luisella, Cozzi Ilaria, Testa Joseph R, Ascoli Valeria

Abstract excerpt

We report a family with domestic exposure to asbestos and diagnosis of multiple cancers, including eight pleural malignant mesotheliomas and several other lung or pleural tumors. DNA sequence analysis revealed no evidence for an inherited mutation of BAP1. Sequence analysis of other potentially relevant genes, including TP53, CDKN2A, and BARD1, also revealed no mutation. DNA microarray analysis of tissue from two...

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Topics

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Share to Asbestos
Share to Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesothelioma

Share to Mesothelioma, Malignant

Share to Oligonucleotide Array Sequence Analysis

Share to Pleural Neoplasms

Share to Tumor Suppressor Proteins

Share to Ubiquitin Thiolesterase

Source

Open in PubMed Open full text

Identifiers

PMID: 26364129
DOI: 10.1016/j.cancergen.2015.07.004
PMCID: PMC4608746

Genes

BAP1
BARD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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