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Article

Dynamic relocalization of NHERF1 mediates chemotactic migration of ovarian cancer cells toward lysophosphatidic acid stimulation.

Experimental & molecular medicine - 7 Jul 2017

Oh Yong-Seok, Heo Kyun, Kim Eung-Kyun, Jang Jin-Hyeok, Bae Sun Sik, Park Jong Bae, Kim Yun Hee, Song Minseok, Kim Sang Ryong, Ryu Sung Ho, Kim In-Hoo, Suh Pann-Ghill

Abstract excerpt

NHERF1/EBP50 (Na+/H+ exchanger regulating factor 1; Ezrin-binding phosphoprotein of 50 kDa) organizes stable protein complexes beneath the apical membrane of polar epithelial cells. By contrast, in cancer cells without any fixed polarity, NHERF1 often localizes in the cytoplasm. The regulation of cytoplasmic NHERF1 and its role in cancer progression remain unclear. In this study, we found that, upon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28684865
DOI: 10.1038/emm.2017.88
PMCID: PMC5565956

Genes

NHERF1
LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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