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Article

NHERF1/EBP50 controls lactation by establishing basal membrane polarity complexes with prolactin receptor.

Cell death & disease - 20 Sept 2012

Morales F C, Hayashi Y, van Pelt C S, Georgescu M-M

Abstract excerpt

The development of the lactating mammary gland is a complex multifactorial process occurring in mammals during pregnancy. We show here that this process requires NHERF1/EBP50 (Na/H exchanger regulatory factor 1/ERM-binding phosphoprotein 50) expression and that successful lactation depends on NHERF1 allele copy number, with rates of 50 and 20% in NHERF1(+/-) and (-/-) mice, respectively. The prolactin receptor...

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Source

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Identifiers

PMID: 22992649
DOI: 10.1038/cddis.2012.131
PMCID: PMC3461366

Genes

NHERF1
PRLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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