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Article

Ezrin Ser66 phosphorylation regulates invasion and metastasis of esophageal squamous cell carcinoma cells by mediating filopodia formation.

The international journal of biochemistry & cell biology - 1 Jul 2017

Li Li-Yan, Xie Ying-Hua, Xie Yang-Min, Liao Lian-Di, Xu Xiu-E, Zhang Qiang, Zeng Fa-Min, Tao Li-Hua, Xie Wen-Ming, Xie Jian-Jun, Xu Li-Yan, Li En-Min

Abstract excerpt

BACKGROUND: Ezrin, links the plasma membrane to the actin cytoskeleton, and plays an important role in the development and progression of human esophageal squamous cell carcinoma (ESCC). However, the roles of ezrin S66 phosphorylation in tumorigenesis of ESCC remain unclear. METHODS: Distribution of ezrin in membrane and cytosol fractions was examined by analysis of detergent-soluble/-insoluble fractions and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28504189
DOI: 10.1016/j.biocel.2017.05.018

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