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Identification of a Druggable Pathway Controlling Glioblastoma Invasiveness

1 Jul 2017

Abstract excerpt

Diffuse and uncontrollable brain invasion is a hallmark of glioblastoma (GBM), but its mechanism is understood poorly. We developed a 3D ex vivo organotypic model to study GBM invasion. We demonstrate that invading GBM cells upregulate a network of extracellular matrix (ECM) components, including multiple collagens, whose expression correlates strongly with grade and clinical outcome. We identify interferon...

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PMID: 28683323
DOI: 10.1016/j.celrep.2017.06.036

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