Characterization of primary direct-acting antiviral (DAA) drugs resistance mutations in NS5A/NS5B regions of hepatitis C virus with genotype 1a and 1b from patients with chronic hepatitis.

doi:10.1590/S1678-9946202264061

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Article

Characterization of primary direct-acting antiviral (DAA) drugs resistance mutations in NS5A/NS5B regions of hepatitis C virus with genotype 1a and 1b from patients with chronic hepatitis.

Revista do Instituto de Medicina Tropical de Sao Paulo - 1 Jan 2022

Santos Ana Paula de Torres, Silva Vanessa Cristina Martins, Mendes-Corrêa Maria Cássia, Lemos Marcilio Figueiredo, Malta Fernanda de Mello, Santana Rúbia Anita Ferraz, Dastoli Gregório Tadeu Fernando, Castro Vanessa Fusco Duarte de, Pinho João Renato Rebello, Moreira Regina Célia

Abstract excerpt

The Hepatitis C virus (HCV) infection is a public health problem. The high level of HCV replication and its lack of post-transcriptional correction mechanisms results in the emergence of viral variants and the difficulty in determining polymorphisms and variants that contain the substitutions associated with resistance towards new antivirals. The main focus of this study was to map the NS5A and NS5B polymorphisms...

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Identifiers

PMID: 36197422
DOI: 10.1590/S1678-9946202264061
PMCID: PMC9528309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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