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Article

Naturally occurring resistance mutations to inhibitors of HCV NS5A region and NS5B polymerase in DAA treatment-naïve patients.

Virology journal - 17 Dec 2013

Paolucci Stefania, Fiorina Loretta, Mariani Bianca, Gulminetti Roberto, Novati Stefano, Barbarini Giorgio, Bruno Raffaele, Baldanti Fausto

Abstract excerpt

BACKGROUND: Direct-acting antiviral (DAA) agents target HCV proteins; some of these have already been approved for the treatment of HCV infection, while others are in development. However, selection of DAA-resistant viral variants may hamper treatment. The aim of this study was to illustrate potential natural DAA-resistance mutations in the HCV NS5A and NS5B regions of HCV genotypes 1a and 1b from DAA-naïve...

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Share to Antiviral Agents
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepacivirus

Share to Hepatitis C

Share to Mutation, Missense

Share to RNA, Viral

Share to Sequence Analysis, DNA

Share to Viral Nonstructural Proteins

Source

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Identifiers

PMID: 24341898
DOI: 10.1186/1743-422X-10-355
PMCID: PMC3878512

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