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Article

Resistance to direct antiviral agents in patients with hepatitis C virus infection.

Gastroenterology - 1 Feb 2010

Sarrazin Christoph, Zeuzem Stefan

Abstract excerpt

Chronic hepatitis C virus (HCV) infection is one of the major causes of cirrhosis, hepatocellular carcinoma, and liver failure that leads to transplantation. The current standard treatment, a combination of pegylated interferon alfa and ribavirin, eradicates the virus in only about 50% of patients. Directly acting antiviral (DAA) agents, which inhibit HCV replication, are in phase 1, 2, and 3 trials; these...

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Identifiers

PMID: 20006612
DOI: 10.1053/j.gastro.2009.11.055

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