Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TRAP1 controls cell cycle G2–M transition through the regulation of CDK1 and MAD2 expression/ubiquitination

5 Jul 2017

Abstract excerpt

Regulation of tumour cell proliferation by molecular chaperones is still a complex issue. Here, the role of the HSP90 molecular chaperone TRAP1 in cell cycle regulation was investigated in a wide range of human breast, colorectal, and lung carcinoma cell lines, and tumour specimens. TRAP1 modulates the expression and/or the ubiquitination of key cell cycle regulators through a dual mechanism: (i) transcriptional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28678347
DOI: 10.1002/path.4936

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TRAP1 controls cell cycle G2–M transition through the regulation of CDK1 and MAD2 expression/ubiquitinationPMID 28678347Read ↗

TRAP1 is involved in BRAF regulation and downstream attenuation of ERK phosphorylation and cell-cycle progression: a novel target for BRAF-mutated colorectal tumors.Semantic proximity Read ↗

Overexpression of Proteins Involved in Mitotic Progression Underlies High Proliferation and Chromosomal Instability in Androgen Receptor-Low Triple-Negative Breast CancerSemantic proximity Read ↗

CK2α phosphorylates CHIP for oncogenesis: A novel post-translational switch in cancerSemantic proximity Read ↗

CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution?Semantic proximity Read ↗

Long-term breast cancer response to CDK4/6 inhibition defined by TP53-mediated geroconversionSemantic proximity Read ↗

The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLLSemantic proximity Read ↗

Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplificationSemantic proximity Read ↗

R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc.Semantic proximity Read ↗

Cks1 Regulates cdk1 Expression: A Novel Role during Mitotic Entry in Breast Cancer CellsSemantic proximity Read ↗

Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplificationSemantic proximity Read ↗

SMAD4 loss drives chromosomal instability during tumourigenesis via translational reprogrammingSemantic proximity Read ↗

Roquin1 inhibits the proliferation of breast cancer cells by inducing G1/S cell cycle arrest via selectively destabilizing the mRNAs of cell cycle–promoting genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.