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Article

R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc.

Molecular cancer research : MCR - 1 Dec 2018

Lin Tzu-Ping, Li Jingjing, Li Qinlong, Li Xiangyan, Liu Chunyan, Zeng Ni, Huang Jen-Ming, Chu Gina Chia-Yi, Lin Chi-Hung, Zhau Haiyen E, Chung Leland W K, Wu Boyang Jason, Shih Jean C

Abstract excerpt

Prostate cancer is a prevalent public health problem, especially because noncutaneous advanced malignant forms significantly affect the lifespan and quality of life of men worldwide. New therapeutic targets and approaches are urgently needed. The current study reports elevated expression of R1 (CDCA7L/RAM2/JPO2), a c-Myc-interacting protein and transcription factor, in human prostate cancer tissue specimens. In a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30042175
DOI: 10.1158/1541-7786.MCR-16-0346

Genes

HUWE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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