Telomerase reverse transcriptase germline mutations and hepatocellular carcinoma in patients with nonalcoholic fatty liver disease.

doi:10.1002/cam4.1078

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Article

Telomerase reverse transcriptase germline mutations and hepatocellular carcinoma in patients with nonalcoholic fatty liver disease.

Cancer medicine - 1 Aug 2017

Donati Benedetta, Pietrelli Alessandro, Pingitore Piero, Dongiovanni Paola, Caddeo Andrea, Walker Lucy, Baselli Guido, Pelusi Serena, Rosso Chiara, Vanni Ester, Daly Ann, Mancina Rosellina Margherita, Grieco Antonio, Miele Luca, Grimaudo Stefania, Craxi Antonio, Petta Salvatore, De Luca Laura, Maier Silvia, Soardo Giorgio, Bugianesi Elisabetta, Colli Fabio, Romagnoli Renato, Anstee Quentin M, Reeves Helen L, Fracanzani Anna Ludovica, Fargion Silvia, Romeo Stefano, Valenti Luca

Abstract excerpt

In an increasing proportion of cases, hepatocellular carcinoma (HCC) develops in patients with nonalcoholic fatty liver disease (NAFLD). Mutations in telomerase reverse transcriptase (hTERT) are associated with familial liver diseases. The aim of this study was to examine telomere length and germline hTERT mutations as associated with NAFLD-HCC. In 40 patients with NAFLD-HCC, 45 with NAFLD-cirrhosis and 64...

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PMID: 28677271
DOI: 10.1002/cam4.1078
PMCID: PMC5548883

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Source receipt: pubmed, retrieved 5 Sept 2026.

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