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Article

Telomere biology and telomerase mutations in cirrhotic patients with hepatocellular carcinoma.

PloS one - 1 Jan 2017

Donaires Flávia S, Scatena Natália F, Alves-Paiva Raquel M, Podlevsky Joshua D, Logeswaran Dhenugen, Santana Barbara A, Teixeira Andreza C, Chen Julian J-L, Calado Rodrigo T, Martinelli Ana L C

Abstract excerpt

Telomeres are repetitive DNA sequences at linear chromosome termini, protecting chromosomes against end-to-end fusion and damage, providing chromosomal stability. Telomeres shorten with mitotic cellular division, but are maintained in cells with high proliferative capacity by telomerase. Loss-of-function mutations in telomere-maintenance genes are genetic risk factors for cirrhosis development in humans and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28813500
DOI: 10.1371/journal.pone.0183287
PMCID: PMC5558955

Genes

TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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