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Accumulation of Genetic and Epigenetic Alterations in the Background Liver and Emergence of Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease.

Cells - 21 Nov 2021

Hagiwara Satoru, Nishida Naoshi, Ueshima Kazuomi, Minami Yasunori, Komeda Yoriaki, Aoki Tomoko, Takita Masahiro, Morita Masahiro, Chishina Hirokazu, Yoshida Akihiro, Ida Hiroshi, Kudo Masatoshi

Abstract excerpt

The incidence of hepatocellular carcinoma (HCC) related to non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. We analyzed 16 surgically resected HCC cases in which the background liver was pathologically diagnosed as NAFLD. Specimens with Brunt classification grade 3 or higher were assigned as the fibrotic progression group (n = 8), and those with grade 1 or lower were classified as the...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

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Identifiers

PMID: 34831479
DOI: 10.3390/cells10113257
PMCID: PMC8619206

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