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Article

Role of Hakai in m6A modification pathway in Drosophila.

Nature communications - 12 Apr 2021

Wang Yanhua, Zhang Lifeng, Ren Hang, Ma Lijuan, Guo Jian, Mao Decai, Lu Zhongwen, Lu Lijun, Yan Dong

Abstract excerpt

N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is installed by a multi-component writer complex; however, the exact roles of each component remain poorly understood. Here we show that a potential E3 ubiquitin ligase Hakai colocalizes and interacts with other m6A writer components, and Hakai mutants exhibit typical m6A pathway defects in Drosophila, such as lowered m6A levels...

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Identifiers

PMID: 33846330
DOI: 10.1038/s41467-021-22424-5
PMCID: PMC8041851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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