Article
Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation.
Molecular cell - 6 Jul 2017
Song Yan, Botvinnik Olga B, Lovci Michael T, Kakaradov Boyko, Liu Patrick, Xu Jia L, Yeo Gene W
Abstract excerpt
Alternative splicing (AS) generates isoform diversity for cellular identity and homeostasis in multicellular life. Although AS variation has been observed among single cells, little is known about the biological or evolutionary significance of such variation. We developed Expedition, a computational framework consisting of outrigger, a de novo splice graph transversal algorithm to detect AS; anchor, a Bayesian...
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