Article
Slfn2 mutation-induced loss of T-cell quiescence leads to elevated de novo sterol synthesis.
Immunology - 1 Nov 2017
Omar Ibrahim, Rom Oren, Aviram Michael, Cohen-Daniel Leonor, Gebre Abraham K, Parks John S, Berger Michael
Abstract excerpt
Acquisition of a 'quiescence programme' by naive T cells is important to provide a stress-free environment and resistance to apoptosis while preserving their responsiveness to activating stimuli. Therefore, the survival and proper function of naive T cells depends on their ability to maintain quiescence. Recently we demonstrated that by preventing chronic unresolved endoplasmic reticulum (ER) stress, Schlafen2...
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