Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Environmentally sensitive molecular probes reveal mutations and epigenetic 5-methyl cytosine in human oncogenes.

Organic & biomolecular chemistry - 21 Jul 2017

Taskova M, Barducci M C, Astakhova K

Abstract excerpt

There is currently an unmet need for reliable tools that allow for direct detection and quantification of modifications in genomic DNA. For example, in cancer research and clinical diagnostics, target DNA has to be amplified and sequenced in order to reveal mutations. For 5-methylcytosine detection, bisulfite treatment of DNA is applied for the analysis, which often leads to poor specificity and reproducibility...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methylcytosine
Share to KRAS gene
Share to Molecular Probes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Structure

Share to Mutation

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins p21(ras)

Share to Stereoisomerism

Source

Identifiers

PMID: 28654119
DOI: 10.1039/c7ob01147d

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Environmentally sensitive molecular probes reveal mutations and epigenetic 5-methyl cytosine in human oncogenes.PMID 28654119Read ↗

Towards DNA methylation detection using biosensorsSemantic proximity Read ↗

From fluorescence spectra to mutational spectra, a historical overview of DNA-reactive compounds.Semantic proximity Read ↗

Biomarkers of environmental exposure : genetic and epigenetic approachesSemantic proximity Read ↗

Mutant enrichment with 3'-modified oligonucleotides a practical PCR method for detecting trace mutant DNAs.Semantic proximity Read ↗

[DNA methylation analysis in environmental and occupational cancer research].Semantic proximity Read ↗

Singlet oxygen-based photoelectrochemical detection of single-point mutations in the KRAS oncogene.Semantic proximity Read ↗

Chemical approach toward efficient DNA methylation analysis.Semantic proximity Read ↗

Sensitive quantification of somatic mutations using molecular inversion probes.Semantic proximity Read ↗

Fluorescence Sheds Light on DNA Damage, DNA Repair, and Mutations.Semantic proximity Read ↗

Somatic mutation detection in human biomonitoring.Semantic proximity Read ↗

Enhanced asymmetric blocked qPCR method for affordable detection of point mutations in KRAS oncogene.Semantic proximity Read ↗

Current Chemicals Used for Probing DNA Conformational Changes and Detection of Unknown Mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.