Article
From fluorescence spectra to mutational spectra, a historical overview of DNA-reactive compounds.
IARC scientific publications - 1 Jan 1994
Lawley P D
Abstract excerpt
This historical survey has shown the emergence over a period of about 60 years of a coherent view of DNA-reactive carcinogens and their effects. The earliest workers, in the 'pre-Watson-Crick' era, probably thought that the mode of action of carcinogens, then largely comprising polycyclic aromatic hydrocarbons, would be revealed through a relationship to steroid hormones, and that they would have protein...
Topics
- Animals
- Carcinogens
- DNA
- DNA Adducts
- DNA Damage
- DNA Mutational Analysis
- DNA Repair
- History, 20th Century
- Humans
- Mutagens
- Mutation
- Neoplasms