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Article

Chemical approach toward efficient DNA methylation analysis.

Organic & biomolecular chemistry - 7 Jan 2009

Okamoto Akimitsu

Abstract excerpt

The development of a reaction for the detection of the presence/absence of one methyl group in a very long DNA strand is a chemically and biologically challenging research subject. Several newly designed chemical assays for the typing of DNA methylation are reported and discussed in this paper. A new concept of sequence-specific short-term methylation analysis, supported by a chemical basis, is the starting point...

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PMID: 19081937
DOI: 10.1039/b813595a

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