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Article

A cis-eQTL genetic variant of the cancer-testis gene CCDC116 is associated with risk of multiple cancers.

Human genetics - 1 Aug 2017

Qin Na, Wang Cheng, Lu Qun, Huang Tongtong, Zhu Meng, Wang Lihua, Yu Fei, Huang Mingtao, Jiang Yue, Dai Juncheng, Ma Hongxia, Jin Guangfu, Wu Chen, Lin Dongxin, Shen Hongbing, Hu Zhibin

Abstract excerpt

Recent studies have found that cancer-testis (CT) genes, which are expressed predominantly in germ and cancer cells, may be candidate cancer drivers. Because of their crucial roles, genetic variants in these genes may contribute to the development of cancer. Here, we systematically evaluated associations of common variants in CT genes and their promoters for the risk of lung cancer in our initial GWAS (2331 cases...

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PMID: 28653172
DOI: 10.1007/s00439-017-1827-2

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