Article
Functional variants in DCAF4 associated with lung cancer risk in European populations.
Carcinogenesis - 1 May 2017
Liu Hongliang, Liu Zhensheng, Wang Yanru, Stinchcombe Thomas E, Owzar Kouros, Han Younghun, Hung Rayjean J, Brhane Yonathan, McLaughlin John, Brennan Paul, Bickeböller Heike, Rosenberger Albert, Houlston Richard S, Caporaso Neil, Landi Maria T, Brüske Irene, Risch Angela, Wu Xifeng, Ye Yuanqing, Christiani David C, Amos Christopher I, Wei Qingyi
Abstract excerpt
Cullin-RING ubiquitin ligases (CRLs) responsible for substrate specificity of ubiquitination play a key role in cell-cycle control and DNA damage response. In this study, we assessed associations between 16 599 SNPs in 115 CRL genes and lung cancer risk by using summary data of six published genome-wide association studies (GWASs) of 12 160 cases and 16 838 cases of European ancestry. As a result, we identified...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.