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The PRC2 complex epigenetically silences GATA4 to suppress cellular senescence and promote the progression of breast cancer

5 Jun 2024

Abstract excerpt

BACKGROUND: The transcription factor GATA4 is pivotal in cancer development but is often silenced through mechanisms like DNA methylation and histone modifications. This silencing suppresses the transcriptional activity of GATA4, disrupting its normal functions and promoting cancer progression. However, the precise molecular mechanisms and implications of GATA4 silencing in tumorigenesis remain unclear. Here, we...

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PMID: 38843657
DOI: 10.1016/j.tranon.2024.102014

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