Article
The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells.
Cancer research - 1 Feb 2013
Gutschner Tony, Hämmerle Monika, Eissmann Moritz, Hsu Jeff, Kim Youngsoo, Hung Gene, Revenko Alexey, Arun Gayatri, Stentrup Marion, Gross Matthias, Zörnig Martin, MacLeod A Robert, Spector David L, Diederichs Sven
Abstract excerpt
The long noncoding RNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), also known as MALAT-1 or NEAT2 (nuclear-enriched abundant transcript 2), is a highly conserved nuclear noncoding RNA (ncRNA) and a predictive marker for metastasis development in lung cancer. To uncover its functional importance, we developed a MALAT1 knockout model in human lung tumor cells by genomically integrating RNA...
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