Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing.

doi:10.1016/s1097-2765(03)00057-1

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing.

Molecular cell - 1 Feb 2003

Sugimoto Masataka, Kuo Mei-Ling, Roussel Martine F, Sherr Charles J

Abstract excerpt

The p19(Arf) tumor suppressor, a nucleolar protein, binds to Mdm2 to induce p53-dependent cell cycle arrest. Arf also prevents the proliferation of cells lacking Mdm2 and p53, albeit less efficiently. We show that p19(Arf) inhibits production of ribosomal RNA, retarding processing of 47/45S and 32S precursors. These effects correlate with but do not strictly depend upon inhibition of rRNA biosynthesis or cell...

Topics

3T3 Cells
Animals
Cell Cycle
Cell Division
Cell Line
Cell Nucleolus
Cyclin-Dependent Kinase Inhibitor p16
Humans
Mice
Mutation
Nuclear Proteins
Proto-Oncogene Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-mdm2

RNA Processing, Post-Transcriptional

RNA, Ribosomal

RNA, Ribosomal, 5.8S

Signal Transduction

Tumor Suppressor Protein p14ARF

Source

Open in PubMed

Identifiers

PMID: 12620229
DOI: 10.1016/s1097-2765(03)00057-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12620229-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing.PMID 12620229Read ↗

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.Semantic proximity Read ↗

Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23.Semantic proximity Read ↗

Ribosomal Proteins Control Tumor Suppressor Pathways in Response to Nucleolar StressSemantic proximity Read ↗

Small mitochondrial Arf (smArf) protein corrects p53-independent developmental defects of Arf tumor suppressor-deficient mice.Semantic proximity Read ↗

Nucleolar stress with and without p53.Semantic proximity Read ↗

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2Semantic proximity Read ↗

Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11-MDM2-p53 ribosome biogenesis stress checkpoint pathway in human cellsSemantic proximity Read ↗

Ribosomal Proteins RPL37, RPS15 and RPS20 Regulate the Mdm2-p53-MdmX NetworkSemantic proximity Read ↗

N-terminal polyubiquitination and degradation of the Arf tumor suppressor.Semantic proximity Read ↗

ARF function does not require p53 stabilization or Mdm2 relocalization.Semantic proximity Read ↗

Specific Role for Yeast Homologs of the Diamond Blackfan Anemia-associated Rps19 Protein in Ribosome Synthesis.Semantic proximity Read ↗

ARF suppresses 5’-terminal oligopyrimidine mRNA translationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.