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Article

Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing.

Molecular cell - 1 Feb 2003

Sugimoto Masataka, Kuo Mei-Ling, Roussel Martine F, Sherr Charles J

Abstract excerpt

The p19(Arf) tumor suppressor, a nucleolar protein, binds to Mdm2 to induce p53-dependent cell cycle arrest. Arf also prevents the proliferation of cells lacking Mdm2 and p53, albeit less efficiently. We show that p19(Arf) inhibits production of ribosomal RNA, retarding processing of 47/45S and 32S precursors. These effects correlate with but do not strictly depend upon inhibition of rRNA biosynthesis or cell...

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PMID: 12620229
DOI: 10.1016/s1097-2765(03)00057-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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