Biological roles of cytochrome P450 1A1, 1A2, and 1B1 enzymes.

Abstract excerpt

Human cytochrome P450 enzymes (CYPs) play a critical role in various biological processes and human diseases. CYP1 family members, including CYP1A1, CYP1A2, and CYP1B1, are induced by aryl hydrocarbon receptors (AhRs). The binding of ligands such as polycyclic aromatic hydrocarbons activates the AhRs, which are involved in the metabolism (including oxidation) of various endogenous or exogenous substrates. The...

Topics

• Animals
• Cytochrome P-450 CYP1A1
• Cytochrome P-450 CYP1A2
• Cytochrome P-450 CYP1B1
• Disease Models, Animal
• Genetic Predisposition to Disease
• Humans
• Ligands
• Receptors, Aryl Hydrocarbon
• Xenobiotics