Article
BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.
Proceedings of the National Academy of Sciences of the United States of America - 11 Sept 2018
Ngeow Kao Chin, Friedrichsen Hans J, Li Linxin, Zeng Zhiqiang, Andrews Sarah, Volpon Laurent, Brunsdon Hannah, Berridge Georgina, Picaud Sarah, Fischer Roman, Lisle Richard, Knapp Stefan, Filippakopoulos Panagis, Knowles Helen, Steingrímsson Eiríkur, Borden Katherine L B, Patton E Elizabeth, Goding Colin R
Abstract excerpt
The close integration of the MAPK, PI3K, and WNT signaling pathways underpins much of development and is deregulated in cancer. In principle, combinatorial posttranslational modification of key lineage-specific transcription factors would be an effective means to integrate critical signaling events. Understanding how this might be achieved is central to deciphering the impact of microenvironmental cues in...
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