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Article

Novel somatic mutations in heterotrimeric G proteins in melanoma.

Cancer biology & therapy - 1 Jul 2010

Cárdenas-Navia L Isabel, Cruz Pedro, Lin Jimmy C, Rosenberg Steven A, Samuels Yardena

Abstract excerpt

Heterotrimeric guanine nucleotide-binding proteins (G proteins) mediate signals between G-protein coupled receptors and their downstream pathways, and have been shown to be mutated in cancer. In particular, GNAQ was found to be frequently mutated in blue nevi of the skin and uveal melanoma, acting as an oncogene in its mutated form. To further examine the role of heterotrimeric G proteins in malignant melanoma,...

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Topics

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Share to DNA Mutational Analysis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20424519
DOI: 10.4161/cbt.10.1.11949
PMCID: PMC3040832

Genes

GNAQ
GNAZ
GNG10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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