Article
A single amino acid polymorphism in the glycosyltransferase CpsK defines four Streptococcus suis serotypes.
Scientific reports - 22 Jun 2017
Roy David, Athey Taryn B T, Auger Jean-Philippe, Goyette-Desjardins Guillaume, Van Calsteren Marie-Rose, Takamatsu Daisuke, Okura Masatoshi, Teatero Sarah, Alcorlo Martín, Hermoso Juan A, Segura Mariela, Gottschalk Marcelo, Fittipaldi Nahuel
Abstract excerpt
The capsular polysaccharide (CPS) is the major virulence factor of the emerging zoonotic pathogen Streptococcus suis. CPS differences are also the basis for serological differentiation of the species into 29 serotypes. Serotypes 2 and 1/2, which possess identical gene content in their cps loci, express CPSs that differ only by substitution of galactose (Gal) by N-acetylgalactosamine (GalNAc) in the CPS side...
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