Article
Putatively novel serotypes and the potential for reduced vaccine effectiveness: capsular locus diversity revealed among 5405 pneumococcal genomes.
Microbial genomics - 1 Oct 2016
van Tonder Andries J, Bray James E, Quirk Sigríður J, Haraldsson Gunnsteinn, Jolley Keith A, Maiden Martin C J, Hoffmann Steen, Bentley Stephen D, Haraldsson Ásgeir, Erlendsdóttir Helga, Kristinsson Karl G, Brueggemann Angela B
Abstract excerpt
The pneumococcus is a leading global pathogen and a key virulence factor possessed by the majority of pneumococci is an antigenic polysaccharide capsule ('serotype'), which is encoded by the capsular (cps) locus. Approximately 100 different serotypes are known, but the extent of sequence diversity within the cps loci of individual serotypes is not well understood. Investigating serotype-specific sequence...
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