CpsK of Streptococcus agalactiae exhibits alpha2,3-sialyltransferase activity in Haemophilus ducreyi.

doi:10.1046/j.1365-2958.2002.02988.x

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Article

CpsK of Streptococcus agalactiae exhibits alpha2,3-sialyltransferase activity in Haemophilus ducreyi.

Molecular microbiology - 1 Jul 2002

Chaffin Donald O, McKinnon Katherine, Rubens Craig E

Abstract excerpt

Streptococcus agalactiae (GBS) is a major cause of serious newborn bacterial infections. Crucial to GBS evasion of host immunity is the production of a capsular polysaccharide (CPS) decorated with sialic acid, which inactivates the alternative complement pathway. The CPS operons of serotypes Ia and III GBS have been described, but the CPS sialyltransferase gene was not identified. We identified cpsK, an open...

Topics

Amino Acid Sequence
Bacterial Proteins
Chromatography, High Pressure Liquid
Codon
Electrophoresis, Polyacrylamide Gel
Haemophilus ducreyi
Humans
Lipopolysaccharides
Molecular Sequence Data
Mutation
Sialyltransferases
Streptococcus agalactiae
beta-Galactoside alpha-2,3-Sialyltransferase

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PMID: 12100552
DOI: 10.1046/j.1365-2958.2002.02988.x

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