Article
The diversity of Klebsiella pneumoniae surface polysaccharides.
Microbial genomics - 1 Aug 2016
Follador Rainer, Heinz Eva, Wyres Kelly L, Ellington Matthew J, Kowarik Michael, Holt Kathryn E, Thomson Nicholas R
Abstract excerpt
Klebsiella pneumoniae is considered an urgent health concern due to the emergence of multi-drug-resistant strains for which vaccination offers a potential remedy. Vaccines based on surface polysaccharides are highly promising but need to address the high diversity of surface-exposed polysaccharides, synthesized as O-antigens (lipopolysaccharide, LPS) and K-antigens (capsule polysaccharide, CPS), present in K....
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