Article
Replication of Gout/Urate Concentrations GWAS Susceptibility Loci Associated with Gout in a Han Chinese Population.
Scientific reports - 22 Jun 2017
Li Zhiqiang, Zhou Zhaowei, Hou Xu, Lu Dajiang, Yuan Xuan, Lu Jie, Wang Can, Han Lin, Cui Lingling, Liu Zhen, Chen Jianhua, Cheng Xiaoyu, Zhang Keke, Ji Jue, Jia Zhaotong, Ma Lidan, Xin Ying, Liu Tian, Yu Qing, Ren Wei, Wang Xuefeng, Li Xinde, Mi Qing-Sheng, Shi Yongyong, Li Changgui
Abstract excerpt
Gout is a chronic disease resulting from elevated serum urate (SU). Previous genome-wide association studies (GWAS) have identified dozens of susceptibility loci for SU/gout, but few have been conducted for Chinese descent. Here, we try to extensively investigate whether these loci contribute to gout risk in Han Chinese. A total of 2255 variants in linkage disequilibrium (LD) with GWAS identified SU/gout...
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