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Article

Effects of multiple genetic loci on the pathogenesis from serum urate to gout.

Scientific reports - 2 Mar 2017

Dong Zheng, Zhou Jingru, Jiang Shuai, Li Yuan, Zhao Dongbao, Yang Chengde, Ma Yanyun, Wang Yi, He Hongjun, Ji Hengdong, Yang Yajun, Wang Xiaofeng, Xu Xia, Pang Yafei, Zou Hejian, Jin Li, Wang Jiucun

Abstract excerpt

Gout is a common arthritis resulting from increased serum urate, and many loci have been identified that are associated with serum urate and gout. However, their influence on the progression from elevated serum urate levels to gout is unclear. This study aims to explore systematically the effects of genetic variants on the pathogenesis in approximately 5,000 Chinese individuals. Six genes (PDZK1, GCKR, TRIM46,...

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Topics

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Share to Disease Progression
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Loci

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Source

Open in PubMed Open full text

Identifiers

PMID: 28252667
DOI: 10.1038/srep43614
PMCID: PMC5333621

Genes

TRIM46
ABCG2
GCKR
PDZK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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