Article
Regulation of RhoA by STAT3 coordinates glial scar formation.
The Journal of cell biology - 7 Aug 2017
Renault-Mihara Francois, Mukaino Masahiko, Shinozaki Munehisa, Kumamaru Hiromi, Kawase Satoshi, Baudoux Matthieu, Ishibashi Toshiki, Kawabata Soya, Nishiyama Yuichiro, Sugai Keiko, Yasutake Kaori, Okada Seiji, Nakamura Masaya, Okano Hideyuki
Abstract excerpt
Understanding how the transcription factor signal transducer and activator of transcription-3 (STAT3) controls glial scar formation may have important clinical implications. We show that astrocytic STAT3 is associated with greater amounts of secreted MMP2, a crucial protease in scar formation. Moreover, we report that STAT3 inhibits the small GTPase RhoA and thereby controls actomyosin tonus, adhesion turnover,...
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