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Article

Interleukin-1beta induces a reactive astroglial phenotype via deactivation of the Rho GTPase-Rock axis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Mar 2004

John Gareth R, Chen Lanfen, Rivieccio Mark A, Melendez-Vasquez Carmen V, Hartley Adam, Brosnan Celia F

Abstract excerpt

The cytokine interleukin-1beta (IL-1beta) is critical to the formation of an astrocytic scar after CNS injury, but the mechanisms by which it induces a reactive phenotype remain unresolved. Here, we show that IL-1beta regulates the phenotype of astrocytes via deactivation of the Rho GTPase-Rho ki...

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Identifiers

PMID: 15028778
DOI: 10.1523/JNEUROSCI.4789-03.2004
PMCID: PMC6729504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15028778-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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