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Exploring the Role of MMP9 and its Association with TGFβ Signalling in Patients with Mesial Temporal Lobe Epilepsy-Hippocampal Sclerosis

2023-07-25

Abstract excerpt

Inflammation and blood brain barrier (BBB) damage are associated with epileptogenesis in Mesial Temporal lobe epilepsy with Hippocampal sclerosis (MTLE-HS). Animal studies have predicted the role of Matrix metalloproteinase 9 (MMP9) in extracellular matrix (ECM) modulation, BBB leakage and neuro-inflammation, while Transforming growth factor beta (TGFβ) signalling in astrocytes potentiates hyper-excitability leadi...

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Literature Corpus work
261c82b8-41c7-5e34-a47f-ae1cc9764035
DOI
10.1101/2023.07.22.550041
Open publication

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Exploring the Role of MMP9 and its Association with TGFβ Signalling in Patients with Mesial Temporal Lobe Epilepsy-Hippocampal SclerosisDOI 10.1101/2023.07.22.550041
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