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Dysregulated long non-coding RNA in Sjögren’s disease impacts both interferon and adaptive immune responses

1 Nov 2022

Abstract excerpt

Objective Sjögren’s disease (SjD) is an autoimmune disease characterised by inflammatory destruction of exocrine glands. Patients with autoantibodies to Ro/SSA (SjDRo+) exhibit more severe disease. Long non-coding RNAs (lncRNAs) are a functionally diverse class of non-protein-coding RNAs whose role in autoimmune disease pathology has not been well characterised. Methods Whole blood RNA-sequencing (RNA-seq) was...

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PMID: 36456101
DOI: 10.1136/rmdopen-2022-002672

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