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Identification of Epigenetic Alteration of the IFI44L Gene in B Cells of Sjogren’s Syndrome as a Clinical Biomarker and Molecular Significance

1 Feb 2025

Abstract excerpt

Objective: Type 1 interferon (IFN-I)-related genes play a critical role in Sjögren’s syndrome (SS). However, study on its role and impact in peripheral blood B cells of SS is limited. This study investigated gene expression and epigenetic changes in IFI44L, analyzing its correlation with disease activity and clinical indicators. Methods: Differentially expressed genes (DEGs) were identified from the GSE199868...

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PMID: 39991660
DOI: 10.2147/jir.s503309

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